Adcy10^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Adcy10^tm1Lex
• Name: adenylate cyclase 10; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3529121
• Synonyms: Lex/Sacytm1 KO, sAC-, Sacy^-, Sacy^tm1Jgo, Sacy^tm1Lex, Sacy^tmLex
• Gene: Adcy10 Location: Chr1:165312752-165404343 bp, + strand Genetic Position: Chr1, 72.83 cM
• Alliance: Adcy10^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88649
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ gene replaced exons 2, 3, and 4. In situ analysis confirmed the absence of endogenous protein in the testis. RT-PCR showed a very low level of transcript expression in the testis that is likely due to read through of the IRES-lacZ cassette. This mutant transcript cannot produce functional protein due to frameshift mutations. (J:88649)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adcy10 Mutation: 84 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:88649 Esposito G, et al., Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2993-8
• All: 21 reference(s)