Ap4b1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Ap4b1^tm1Lex
• Name: adaptor-related protein complex AP-4, beta 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3529172
• Gene: Ap4b1 Location: Chr3:103716836-103729341 bp, + strand Genetic Position: Chr3, 45.52 cM
• Alliance: Ap4b1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:135974
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ/neo cassette. The absence of protein product was confirmed by western blot analysis on brain extracts. This is a null allele and a reporter allele. (J:135974)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ap4b1 Mutation: 34 strains or lines available

References

• Original: J:135974 Matsuda S, et al., Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Neuron. 2008 Mar 13;57(5):730-45
• All: 1 reference(s)