Impa1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Impa1^tm1Lex
• Name: inositol (myo)-1(or 4)-monophosphatase 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3529209
• Gene: Impa1 Location: Chr3:10377016-10396499 bp, - strand Genetic Position: Chr3, 2.61 cM
• Alliance: Impa1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157887
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 664 bp genomic sequence containing exons 2 and 3 was replaced with an IRES-lacZ/neo cassette. Reduced expression of a truncated transcript was confirmed by RT-PCR on liver, spinal cord, brain, kidney, and heart extracts. (J:157887)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Impa1 Mutation: 22 strains or lines available

References

• Original: J:157887 Cryns K, et al., IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity. Neuropsychopharmacology. 2008 Feb;33(3):674-84
• All: 3 reference(s)