Fscn1^{Gt(OST124903)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Fscn1^{Gt(OST124903)Lex}
• Name: fascin actin-bundling protein 1; gene trap OST124903, Lexicon Genetics
• MGI ID: MGI:3529245
• Synonyms: fascin 1^-, Fscn1^Gt(neo)83Lex
• Gene: Fscn1 Location: Chr5:142946110-142958944 bp, + strand Genetic Position: Chr5, 81.84 cM
• Alliance: Fscn1^{Gt(OST124903)Lex} page

Mutation origin

• Mutant Cell Line: OST124903
• Germline Transmission: Earliest citation of germline transmission: J:205179
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted between exon 1 and 2. Western blot analysis confirmed the complete absence of protein expression in various tissues of homozygous mutant mice, including adult and embryonic brain, liver, placenta and spleen. (J:205179)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST124903	CG536686 ; (MGI Seq Detail)	3' RACE	Chr5:142955657-142957698 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  9 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fscn1 Mutation: 42 strains or lines available

References

• Original: J:205179 Yamakita Y, et al., Fascin1 is dispensable for mouse development but is favorable for neonatal survival. Cell Motil Cytoskeleton. 2009 Aug;66(8):524-34
• All: 9 reference(s)