Ldlrap1^{Gt(OST149604)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Ldlrap1^{Gt(OST149604)Lex}
• Name: low density lipoprotein receptor adaptor protein 1; gene trap OST149604, Lexicon Genetics
• MGI ID: MGI:3529295
• Synonyms: ARH^-, Ldlrap1^Gt(neo)98Lex
• Gene: Ldlrap1 Location: Chr4:134468865-134495335 bp, - strand Genetic Position: Chr4, 67.09 cM
• Alliance: Ldlrap1^{Gt(OST149604)Lex} page

Mutation origin

• Mutant Cell Line: OST149604
• Germline Transmission: Earliest citation of germline transmission: J:102291
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector contained a promoterless splice acceptor sequence and a betageo, as well as a long terminal repeat, a PGK promoter and Bruton tyrosine kinase, and a splice donor sequence. RT-PCR failed to detect transcript in mutant mice. (J:102291)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST149604	CG548224 ; (MGI Seq Detail)	3' RACE	Chr4:134477269-134482619 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  3 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldlrap1 Mutation: 20 strains or lines available

References

• Original: J:102291 Harada-Shiba M, et al., Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo. Circ Res. 2004 Oct 29;95(9):945-52
• All: 2 reference(s)