Aurkc^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Aurkc^tm1Lex
• Name: aurora kinase C; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3529317
• Synonyms: Aurkc^-
• Gene: Aurkc Location: Chr7:6998346-7006090 bp, + strand Genetic Position: Chr7, 4.06 cM, cytoband A2-A3
• Alliance: Aurkc^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142947
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2, 3, and 4 were replaced with a lacZ/neomycin cassette. (J:142947)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aurkc Mutation: 11 strains or lines available

References

• Original: J:142947 Kimmins S, et al., Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis. Mol Endocrinol. 2007 Mar;21(3):726-39
• All: 7 reference(s)