Adamts5^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Adamts5^tm1Lex
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 5; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3529332
• Gene: Adamts5 Location: Chr16:85655045-85698013 bp, - strand Genetic Position: Chr16, 48.34 cM
• Alliance: Adamts5^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105138
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was flanked with loxP sites. (J:105138)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adamts5 Mutation: 56 strains or lines available

References

• Original: J:105138 Stanton H, et al., ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature. 2005 Mar 31;434(7033):648-52
• All: 1 reference(s)