Cia30^B10.RIII
QTL Variant Detail

Summary

• QTL variant: Cia30^B10.RIII
• Name: collagen induced arthritis QTL 30; B10.RIII
• MGI ID: MGI:3529500
• QTL: Cia30 Location: unknown Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: B10.RIII

Variant description

• Allele Type: QTL
• Inheritance: Dominant

Notes

Homozygous RIIIS/J-derived alleles at Cia26 interact with B10.RIII-derived alleles at Cia30 to promote severe CIA and increase disease incidence in female animals.

Interaction between Cia30 and Cia5 on mouse Chromosome 3 affects late phase arthritis severity in male and female animals.

References

• Original: J:95848 Karlsson J, et al., Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio. J Immunol. 2005 Jan 1;174(1):533-41
• All: 2 reference(s)