Cia31^B10.RIII
QTL Variant Detail

Summary

• QTL variant: Cia31^B10.RIII
• Name: collagen induced arthritis QTL 31; B10.RIII
• MGI ID: MGI:3529502
• QTL: Cia31 Location: unknown Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: B10.RIII

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers early CIA onset and increased CIA severity compared to RIIIS/J. (J:95848)
• Inheritance: Dominant

Notes

Cia31 interacts with Cia5 on mouse Chromosome 3.

Heterozygosity at Cia31 and RIIIS/J-derived alleles at Cia5 confers delayed onset of collagen-induced arthritis in female animals with an additive effect.

This allele confers early CIA onset and increased CIA severity when the Cia5 locus is homozygous for B10.RIII alleles.

References

• Original: J:95848 Karlsson J, et al., Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio. J Immunol. 2005 Jan 1;174(1):533-41
• All: 2 reference(s)