Cia32^B10.RIII
QTL Variant Detail

Summary

• QTL variant: Cia32^B10.RIII
• Name: collagen induced arthritis QTL 32; B10.RIII
• MGI ID: MGI:3529504
• QTL: Cia32 Location: unknown Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: B10.RIII

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers susceptibility to collagen induced arthritis in female animals compared to RIIIS/J. (J:95848)
• Inheritance: Dominant

Notes

Cia32 interacts with Cia5, Cia21, and Cia22 on mouse Chromosome 3.

Interaction between Cia5 and Cia32 affects arthritis severity in the early and late phases of disease in both male and female animals. This allele confers aggressive development of CIA disease in female animals when the Cia5 locus is homozygous for B10.RIII alleles.

Heterozygosity at Cia32 and RIIIS/J-derived alleles at Cia21 decreases arthritis score in female animals with a dominant effect.

Interaction between Cia32 and Cia22 affects arthritis severity in female animals.

References

• Original: J:95848 Karlsson J, et al., Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio. J Immunol. 2005 Jan 1;174(1):533-41
• All: 2 reference(s)