Cia32^RIIIS/J
QTL Variant Detail

Summary

• QTL variant: Cia32^RIIIS/J
• Name: collagen induced arthritis QTL 32; RIIIS/J
• MGI ID: MGI:3529505
• QTL: Cia32 Location: unknown Genetic Position: Chr15, Syntenic

Variant origin

• Strain of Specimen: RIIIS/J

Variant description

• Allele Type: QTL
• Inheritance: Recessive

Notes

Cia32 interacts with Cia5, Cia21, and Cia22 on mouse Chromosome 3.

Interaction between Cia32 and Cia5 affects arthritis severity in the early and late phases of disease in male and female animals.

Heterozygosity at Cia32 and RIIIS/J-derived alleles at Cia21 decreases arthritis score in female animals with a dominant effect.

Interaction between Cia32 and Cia22 affects arthritis severity in female animals.

References

• Original: J:95848 Karlsson J, et al., Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio. J Immunol. 2005 Jan 1;174(1):533-41
• All: 2 reference(s)