Sult1e1^tm1Song
Targeted Allele Detail

Summary

• Symbol: Sult1e1^tm1Song
• Name: sulfotransferase family 1E, member 1; targeted mutation 1, Wen-Chao Song
• MGI ID: MGI:3529586
• Synonyms: EST^-
• Gene: Sult1e1 Location: Chr5:87723828-87739453 bp, - strand Genetic Position: Chr5, 43.56 cM
• Alliance: Sult1e1^tm1Song page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96133
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 3 via homologous recombination. Northern and Western blot analysis confirmed that no mRNA and protein of either normal or aberrant size were present. Sult1e1 enzyme activity in the testis was also not detected. (J:96133)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sult1e1 Mutation: 20 strains or lines available

References

• Original: J:96133 Qian YM, et al., Targeted disruption of the mouse estrogen sulfotransferase gene reveals a role of estrogen metabolism in intracrine and paracrine estrogen regulation. Endocrinology. 2001 Dec;142(12):5342-50
• All: 14 reference(s)