Nod2^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Nod2^tm1Flv
• Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3529594
• Synonyms: Nod2^-
• Gene: Nod2 Location: Chr8:89373943-89415102 bp, + strand Genetic Position: Chr8, 43.51 cM, cytoband C3
• Alliance: Nod2^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96035
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neo replaced exon 3, encoding the CARD domain and P-loop of the NOD domain. Spleens of mutant animals demonstrated a lack of protein by immunoblot analysis. (J:96035)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nod2 Mutation: 63 strains or lines available

References

• Original: J:96035 Kobayashi KS, et al., Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 2005 Feb 4;307(5710):731-4
• All: 145 reference(s)