Tg(Ins2-CDKN1B)1Maka
Transgene Detail

Summary

• Symbol: Tg(Ins2-CDKN1B)1Maka
• Name: transgene insertion 1, Masato Kasuga
• MGI ID: MGI:3529600
• Synonyms: RIP-CDKN1B
• Transgene: Tg(Ins2-CDKN1B)1Maka Location: unknown
• Alliance: Tg(Ins2-CDKN1B)1Maka page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-CDKN1B)1Maka expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CDKN1B (1027)

  Cdkn1b

  (MGI:104565)

• Tg(Ins2-CDKN1B)1Maka expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: The rat insulin promoter drives expression of the human CDNK1B gene. Immunoblot analysis with an antibody that recognizes both the mouse and human protein indicates that expression of CDNK1B is increased 6.2-fold compared to non-transgenic littermates. (J:96047)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:96047 Uchida T, et al., Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat Med. 2005 Feb;11(2):175-82
• All: 1 reference(s)