Cckar^tm1Kym
Targeted Allele Detail

Summary

• Symbol: Cckar^tm1Kym
• Name: cholecystokinin A receptor; targeted mutation 1, Kyoko Miyasaka
• MGI ID: MGI:3529601
• Synonyms: CCK-1R^-, CCK-AR^-
• Gene: Cckar Location: Chr5:53855827-53865046 bp, - strand Genetic Position: Chr5, 29.52 cM
• Alliance: Cckar^tm1Kym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96137
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 and all of exon 2, encoding the first 122 amino acids and the first transmembrane-spanning region, was replaced with an NLS-lacZ neo. Northern blot analysis of mutant kidneys demonstrated a complete lack of transcript.. (J:96137)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cckar Mutation: 41 strains or lines available

References

• Original: J:96137 Takiguchi S, et al., Role of CCK-A receptor for pancreatic function in mice: a study in CCK-A receptor knockout mice. Pancreas. 2002 Apr;24(3):276-83
• All: 10 reference(s)