Msrb1^{Gt(OST336894)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Msrb1^{Gt(OST336894)Lex}
• Name: methionine sulfoxide reductase B1; gene trap OST336894, Lexicon Genetics
• MGI ID: MGI:3529701
• Synonyms: MsrB1^-
• Gene: Msrb1 Location: Chr17:24955616-24961752 bp, + strand Genetic Position: Chr17, 12.53 cM
• Alliance: Msrb1^{Gt(OST336894)Lex} page

Mutation origin

• Mutant Cell Line: OST336894
• Germline Transmission: Earliest citation of germline transmission: J:147916
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector inserted downstream of exon 1. The absence of protein expression was confirmed by western blot analysis on liver, heart, kidney, testis, and lung extracts. (J:147916)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST336894	CG627251 ; (MGI Seq Detail)	3' RACE	Chr17:24958479-24961469 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  4 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Generation of the Msrb1^{Gt(OST336894)Lex} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msrb1 Mutation: 8 strains or lines available

References

• Original: J:147916 Fomenko DE, et al., MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. J Biol Chem. 2009 Feb 27;284(9):5986-93
• All: 7 reference(s)