Tpcn1^{Gt(OST359423)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Tpcn1^{Gt(OST359423)Lex}
• Name: two pore channel 1; gene trap OST359423, Lexicon Genetics
• MGI ID: MGI:3529820
• Synonyms: Tpcn1^{Gt(IRESBetageo)258Lex}
• Gene: Tpcn1 Location: Chr5:120672222-120726731 bp, - strand Genetic Position: Chr5, 60.63 cM
• Alliance: Tpcn1^{Gt(OST359423)Lex} page

Mutation origin

• Mutant Cell Line: OST359423
• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Retroviral insertion occurred between coding exons 1 and 2 (NM_145853). RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. (J:82809)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST359423	CG635881 ; (MGI Seq Detail)	3' RACE	Chr5:120693937-120696060 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  14 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tpcn1 Mutation: 70 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 2 reference(s)