Rrm2b^{Gt(OST85254)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Rrm2b^{Gt(OST85254)Lex}
• Name: ribonucleotide reductase M2 B (TP53 inducible); gene trap OST85254, Lexicon Genetics
• MGI ID: MGI:3529827
• Synonyms: Rrm2b^{Gt(neo)263Lex}
• Gene: Rrm2b Location: Chr15:37924196-37961562 bp, - strand Genetic Position: Chr15, 15.1 cM
• Alliance: Rrm2b^{Gt(OST85254)Lex} page

Mutation origin

• Mutant Cell Line: OST85254
• Germline Transmission: Earliest citation of germline transmission: J:94338
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing a neomycin selection cassette was inserted in intron 1 downstream of the ATG initiation site. RT-PCR analysis demonstrated absence of mRNA in kidney and spleen of homozygous mutant mice. (J:186071)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST85254	CG520243 ; (MGI Seq Detail)	3' RACE	Chr15:37944760-37953968 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rrm2b Mutation: 27 strains or lines available

References

• Original: J:94338 NIH Mouse Knockout Inventory, Information obtained from the NIH Mouse Knockout Inventory. MGI Direct Data Submission. 2004
• All: 6 reference(s)