Summary |
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Variant origin |
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Variant description |
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Phenotypes |
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View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
This allele shows linkage to increased anti-chromatin and anti-DNA antibodies, increased serum gp70 immune complex levels, and severe glomerulonephritis.
Mapping and Phenotype information for this QTL, its variants and associated markersJ:95829Linkage analysis was performed on 154 male animals from a C57BL/6 x (NZB x C57BL/6-Yaa)F1 backcross to map QTLs associated with autoimmune traits, such as anti-DNA and anti-chromatin antibody production. Parental strain C57BL/6 does not develop spontaneous autoimmune traits whereas the parental hybrid (NZB x C57BL/6-Yaa)F1 develops lupus-like nephritis and increased serum IgG anti-DNA antibodies and gp70-anti-gp70 immune complex. 95 microsatellite markers were used for the genome scan. An interval from90 cM - 98 cM on mouse Chromosome 1 that overlapped with the previously identified Nba2 QTL showed linkage to anti-DNA (LOD=7.08) and anti-chromatin antibodies (LOD=13.24). Peak linkage occurred near Fcgr2b (92.3 cM). The NZB-derived allele confers susceptibility to autoimmunity at this locus. This locus also shows linkage to gp70 immune complex levels (LOD=7.28). Markers D1Mit36 and Fcgr2b in the region also show linkage to glomerulonephritis. Heterozygous animals exhibit more severe glomerulonephritisthan C57BL/6 homozygous animals. Male congenic animals carrying an NZB-derived locus (from D1Mit47 - D1Mit461) on a C57BL/6-Yaa genetic background exhibit increased anti-DNA, anti-chromatin antibodies, and gp70 immune complex levels and severe glomerulonephritis (50% mortality rate at 14 months of age) compared to control male C57BL/6-Yaa animals. Potential candidate genes are Fcgr2b (92.3 cM) and Ifi202a (95.3 cM).07.16.2015. Curators Note: Because Nba2 was orginally mapped in J:23719 in 1995 using 90 female (NZB x SM/J)F1 x NZW backcross mice, which differ from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Nba10 . The H2 locus at 23 cM on mouse Chromosome 17 showed linkage to anti-DNA (LOD=10.55) and anti-chromatin antibodies(3.02). The C57BL/6-derived allele confers susceptibility to autoimmunity at this locus. This locus is also linked to serum gp70 immune complex levels (LOD=8.9). A locus on mouse Chromosome 13 named Sgp3 showed linkagetoserum gp70 production with peak linkage occurring near D13Mit193 (43 cM; LOD=8.77). Sgp3 is also strongly linked to gp70 immune complex levels (LOD=8.27). Markers D13Mit250 and D13Mit122 in the Sgp3 region also show linkage to glomerulonephritis. Animalsheterozygous at Sgp3 exhibit more severe glomerulonephritis than C57BL/6 homozygous animals. Male congenic animals carrying an NZB-derived Sgp3 locus (from D13Mit250 - D13Mit73) on a C57BL/6-Yaa genetic background exhibit increased serum gp70 levels compared to control male C57BL/6-Yaa animals. A potential candidate gene for Sgp3 is Gv1 at 36 cM.10.8.2015 Curator Note: Because Sgp3 was originally mapped in J:85646 in 2003 using congenic strains, B6.NZW-Sgp3/1, -Sgp3/2 and -Sgp3/3,, which differ from the cross used here, we consider the current study a separate mapping experiment and have named this QTL (mapping to Chr 13, 43 cM; LOD=8.77) Sgp5 . A novel locus showing association to gp70 immune complex levels named Nba5 mapped to 23 cM on mouse Chromosome 7 near D7Nds5 (LOD=4.65). Male congenic animalscarrying an NZB-derived Nba5 locus (from D7Mit154 - D7Mit194) on a C57BL/6-Yaa genetic background exhibit increased serum gp70 immune complex levels. Congenic males also exhibit some increase in severeglomerulonephritis (1/3 mortality rate at 14 monthsof age) compared to control maleC57BL/6-Yaa animals. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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