Mtor^{Gt(OST92090)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Mtor^{Gt(OST92090)Lex}
• Name: mechanistic target of rapamycin kinase; gene trap OST92090, Lexicon Genetics
• MGI ID: MGI:3529989
• Synonyms: Frap1^{Gt(neo)299Lex}, mTOR^-
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^{Gt(OST92090)Lex} page

Mutation origin

• Mutant Cell Line: OST92090
• Germline Transmission: Earliest citation of germline transmission: J:137592
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• The gene trapping vector containing a neo cassette was inserted into intron 1 at position 488. (J:137592)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST92090	CG522435 ; (MGI Seq Detail)	3' RACE	Chr4:148537498-148538435 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  15 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 115 strains or lines available

References

• Original: J:137592 Guertin DA, et al., Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006 Dec;11(6):859-71
• All: 5 reference(s)