Clcn3^tm1Suc
Targeted Allele Detail

Summary

• Symbol: Clcn3^tm1Suc
• Name: chloride channel, voltage-sensitive 3; targeted mutation 1, Shinichi Uchida
• MGI ID: MGI:3530047
• Synonyms: Clnc3^-
• Gene: Clcn3 Location: Chr8:61363423-61436334 bp, - strand Genetic Position: Chr8, 30.9 cM
• Alliance: Clcn3^tm1Suc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96311
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced exons 5 and 6, which encode transmembrane segments D2-D4. Western blot of mutant brain tissue fractions confirmed the absence of protein. (J:96311)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcn3 Mutation: 120 strains or lines available

References

• Original: J:96311 Yoshikawa M, et al., CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells. 2002 Jun;7(6):597-605
• All: 5 reference(s)