Ywhag^tm1Bros
Targeted Allele Detail

Summary

• Symbol: Ywhag^tm1Bros
• Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; targeted mutation 1, Nils Brose
• MGI ID: MGI:3530054
• Synonyms: 14-3-3gamma^-, Ywhag^tm1Otto
• Gene: Ywhag Location: Chr5:135937263-135963470 bp, - strand Genetic Position: Chr5, 75.53 cM
• Alliance: Ywhag^tm1Bros page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95988
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, encoding bp 198-852 of the mRNA, was replaced by a neo cassette. Western blot of mutant brain homogenates confirmed absence of protein. (J:95988)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ywhag Mutation: 34 strains or lines available

References

• Original: J:95988 Steinacker P, et al., Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein. Mol Cell Biol. 2005 Feb;25(4):1339-46
• All: 3 reference(s)