F2rl1^tm1Bpd
Targeted Allele Detail

Summary

• Symbol: F2rl1^tm1Bpd
• Name: F2R like trypsin receptor 1; targeted mutation 1, Bruce P Damiano
• MGI ID: MGI:3530061
• Synonyms: Par2^-, PAR-2^-
• Gene: F2rl1 Location: Chr13:95648240-95661735 bp, - strand Genetic Position: Chr13, 49.53 cM
• Alliance: F2rl1^tm1Bpd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96312
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo replaced the 5' region of exon 2. Northern blot of kidneys from mutant mice demonstrated the absence of transcript. (J:96312)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2rl1 Mutation: 60 strains or lines available

References

• Original: J:96312 Damiano BP, et al., Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J Pharmacol Exp Ther. 1999 Feb;288(2):671-8
• All: 34 reference(s)