Klf10^tm1Sub
Targeted Allele Detail

Summary

• Symbol: Klf10^tm1Sub
• Name: Kruppel-like transcription factor 10; targeted mutation 1, Malayannan Subramaniam
• MGI ID: MGI:3530069
• Synonyms: KLF10^-, TIEG^-
• Gene: Klf10 Location: Chr15:38291707-38300950 bp, - strand Genetic Position: Chr15, 15.15 cM
• Alliance: Klf10^tm1Sub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95992
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2, including transcription and translation start sites and the first 114 amino acids, were replaced with a neo cassette with a polyA signal. Northern blot of mutants confirmed absence of transcript and immunoprecipitation demonstrated the lack of protein in mutants. (J:95992)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Klf10^tm1Sub

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf10 Mutation: 26 strains or lines available

References

• Original: J:95992 Subramaniam M, et al., TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol. 2005 Feb;25(3):1191-9
• All: 36 reference(s)