Tg(Prnp-SNCA)22Dpr
Transgene Detail

Summary

• Symbol: Tg(Prnp-SNCA)22Dpr
• Name: transgene insertion 22, Donald L Price
• MGI ID: MGI:3530087
• Synonyms: Hualpha-Syn(WT), I2-2, MoPrP-Hualpha-Syn(WT)
• Transgene: Tg(Prnp-SNCA)22Dpr Location: unknown
• Alliance: Tg(Prnp-SNCA)22Dpr page

Transgene origin

• Strain of Origin: (C3H/HeJ x C57BL/6J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-SNCA)22Dpr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• The transgene contains a wild-type human alpha synuclein cDNA and the murine prion promoter. (J:77344)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This line was originally designated I2-2. Transgenic mice express high levels of the human protein in the brain, but do not develop neurological abnormalities at any age. These mice do not show obvious abnormal accumulation of human alpha synuclein or ubiquitin.

References

• Original: J:77344 Lee MK, et al., Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8968-73
• All: 12 reference(s)