Tnmd^tm1Ref
Targeted Allele Detail

Summary

• Symbol: Tnmd^tm1Ref
• Name: tenomodulin; targeted mutation 1, Reinhard Fassler
• MGI ID: MGI:3530136
• Synonyms: Tnmd^-
• Gene: Tnmd Location: ChrX:132751757-132766326 bp, + strand Genetic Position: ChrX, 55.47 cM, cytoband E3
• Alliance: Tnmd^tm1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96005
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An IRES-lacZ neo was inserted into exon 1. Northern blot of thymus, eye, tendon, muscle and heart of mutant mice confirmed complete absence of transcript. Western blot further confirmed the absence of protein in mutants. (J:96005)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnmd Mutation: 6 strains or lines available

References

• Original: J:96005 Docheva D, et al., Tenomodulin is necessary for tenocyte proliferation and tendon maturation. Mol Cell Biol. 2005 Jan;25(2):699-705
• All: 5 reference(s)