Srsf1^tm1Xdfu
Targeted Allele Detail

Summary

• Symbol: Srsf1^tm1Xdfu
• Name: serine and arginine-rich splicing factor 1; targeted mutation 1, Xiang-Dong Fu
• MGI ID: MGI:3530151
• Synonyms: ASF/SF2^II, Sfrs1^fl
• Gene: Srsf1 Location: Chr11:87938199-87944581 bp, + strand Genetic Position: Chr11, 52.4 cM
• Alliance: Srsf1^tm1Xdfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96039
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo-tk cassette was inserted downstream of exon 4. The neo-tk cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Resulting mutant animals carry loxP-flanked exons 2-4. (J:96039)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Srsf1 Mutation: 26 strains or lines available

References

• Original: J:96039 Xu X, et al., ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell. 2005 Jan 14;120(1):59-72
• All: 18 reference(s)