Aldh2^{Gt(OST7285)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Aldh2^{Gt(OST7285)Lex}
• Name: aldehyde dehydrogenase 2, mitochondrial; gene trap OST7285, Lexicon Genetics
• MGI ID: MGI:3530243
• Synonyms: Aldh2^{Gt(Betageo)412Lex}
• Gene: Aldh2 Location: Chr5:121704090-121731887 bp, - strand Genetic Position: Chr5, 61.86 cM, cytoband F-G1
• Alliance: Aldh2^{Gt(OST7285)Lex} page

Mutation origin

• Mutant Cell Line: OST7285
• Germline Transmission: Earliest citation of germline transmission: J:152060
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted into intron 2. Western blot analysis confirmed the absence of protein expression in liver mitochondria. (J:152060)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST7285	CG477397 ; (MGI Seq Detail)	3' RACE	Chr5:121714026-121714613 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  19 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aldh2 Mutation: 36 strains or lines available

References

• Original: J:152060 Fernandez E, et al., Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice. Alcohol Clin Exp Res. 2006 Oct;30(10):1650-8
• All: 6 reference(s)