Eae27^RIIIS/J
QTL Variant Detail

Summary

• QTL variant: Eae27^RIIIS/J
• Name: experimental allergic encephalomyelitis susceptibility 27; RIIIS/J
• MGI ID: MGI:3530265
• QTL: Eae27 Location: unknown Genetic Position: Chr1, cM position of peak correlated region/allele: 68.38 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: RIIIS/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers EAE resistance in female animals compared to B10.RIII. (J:96204)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96204

Linkage analysis was performed on 402 animals from a B10.RIII-H2^r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2^r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2^r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan.

Eae27 mapped to 81.6 cM on mouse Chromosome 1 near D1Mit33 (LRS=12.8). RIIIS/J-derived alleles at Eae27 appear to confer EAE resistance in female animals with a dominant mode of inheritance. Previously identified QTL mapping near Eae27 are Cia9 (92.3 cM), Stia1 (81.6 cM), and Orch4 (110 cM).

References

• Original: J:96204 Karlsson J, et al., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol. 2003 Jan 15;170(2):1019-26
• All: 1 reference(s)