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Eae39C57BL/10SnSg
QTL Variant Detail
Summary
QTL variant: Eae39C57BL/10SnSg
Name: experimental allergic encephalomyelitis susceptibility 39; C57BL/10SnSg
MGI ID: MGI:3530266
Synonyms: Eae39B10.RIII-H2r/SgKljLund
QTL: Eae39  Location: Chr5:89418876-118864028 bp  Genetic Position: Chr5, cM position of peak correlated region/allele: 50.68 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  B10.RIII-H2r/SgKljLund
Variant
description
Allele Type:    QTL
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96204

Linkage analysis was performed on 402 animals from a B10.RIII-H2r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan.

Eae39 mapped to 56 cM on mouse Chromosome 5 near D5Mit41 (LRS=18). (Eae39 is referred to as Eae26 in this article.) RIIIS/J-derived alleles at Eae39 appear to confer EAE resistance in male animals with a dominant mode of inheritance. Previously identified QTLs mapping near Eae39 are Pgia16 (36 cM), Bbaa2 (66 cM), and Bbaa3 (45 cM).

References
Original:  J:96204 Karlsson J, et al., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol. 2003 Jan 15;170(2):1019-26
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory