Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:96204Linkage analysis was performed on 402 animals from a B10.RIII-H2r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan. Eae39 mapped to 56 cM on mouse Chromosome 5 near D5Mit41 (LRS=18). (Eae39 is referred to as Eae26 in this article.) RIIIS/J-derived alleles at Eae39 appear to confer EAE resistance in male animals with a dominant mode of inheritance. Previously identified QTLs mapping near Eae39 are Pgia16 (36 cM), Bbaa2 (66 cM), and Bbaa3 (45 cM). |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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