Eae39^RIIIS/J
QTL Variant Detail

Summary

• QTL variant: Eae39^RIIIS/J
• Name: experimental allergic encephalomyelitis susceptibility 39; RIIIS/J
• MGI ID: MGI:3530267
• QTL: Eae39 Location: Chr5:89418876-118864028 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 50.68 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: RIIIS/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers EAE resistance in male animals compared to B10.RIII. (J:96204)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96204

Linkage analysis was performed on 402 animals from a B10.RIII-H2^r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2^r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2^r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan.

Eae39 mapped to 56 cM on mouse Chromosome 5 near D5Mit41 (LRS=18). (Eae39 is referred to as Eae26 in this article.) RIIIS/J-derived alleles at Eae39 appear to confer EAE resistance in male animals with a dominant mode of inheritance. Previously identified QTLs mapping near Eae39 are Pgia16 (36 cM), Bbaa2 (66 cM), and Bbaa3 (45 cM).

References

• Original: J:96204 Karlsson J, et al., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol. 2003 Jan 15;170(2):1019-26
• All: 1 reference(s)