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Eae2bC57BL/10SnSg
QTL Variant Detail
Summary
QTL variant: Eae2bC57BL/10SnSg
Name: experimental allergic encephalomyelitis susceptibility 2b; C57BL/10SnSg
MGI ID: MGI:3530268
Synonyms: Eae2bB10.RIII-H2r/SgKljLund
QTL: Eae2b  Location: Chr15:51004694-64944308 bp  Genetic Position: Chr15, Syntenic
Variant
origin
Strain of Specimen:  B10.RIII-H2r/SgKljLund
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased susceptibility to EAE development compared to RIIIS/J. (J:96204)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
Animals homozygous for B10.RIII-derived alleles exhibit the highest area under the curve (AUC).

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96204

Linkage analysis was performed on 402 animals from a B10.RIII-H2r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan.

On mouse Chromosome 15, a locus including Eae2 (15.5 cM) showed linkage to EAE development (area under the curve-AUC) between markers D15Mit100 (21 cM) and D15Mit234 (34.2 cM). Animals homozygous for B10.RIII-H2r/SgKljLund-derived alleles exhibit the highest AUC. This inheritance pattern is different from what was previously observed with Eae2. Therefore, this locus is thought to be distinct from Eae2 and has been assigned the symbol Eae2b.

On mouse Chromosome 15, Eae2 shows linkage to CD4+/CD8+ T cell ratios in female animals. This phenotype is linked to marker D15Mit150 (12.1 cMc) with an LRS of 13.3.

References
Original:  J:96204 Karlsson J, et al., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol. 2003 Jan 15;170(2):1019-26
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory