Summary |
|
||||||||||
Variant origin |
|
||||||||||
Variant description |
|
||||||||||
Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
|
||||||||||
Notes |
Animals homozygous for B10.RIII-derived alleles exhibit the highest area under the curve (AUC).
Mapping and Phenotype information for this QTL, its variants and associated markersJ:96204Linkage analysis was performed on 402 animals from a B10.RIII-H2r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan. On mouse Chromosome 15, a locus including Eae2 (15.5 cM) showed linkage to EAE development (area under the curve-AUC) between markers D15Mit100 (21 cM) and D15Mit234 (34.2 cM). Animals homozygous for B10.RIII-H2r/SgKljLund-derived alleles exhibit the highest AUC. This inheritance pattern is different from what was previously observed with Eae2. Therefore, this locus is thought to be distinct from Eae2 and has been assigned the symbol Eae2b.On mouse Chromosome 15, Eae2 shows linkage to CD4+/CD8+ T cell ratios in female animals. This phenotype is linked to marker D15Mit150 (12.1 cMc) with an LRS of 13.3. |
||||||||||
References |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 10/29/2024 MGI 6.24 |
|
|