Eae41^C57BL/10SnSg
QTL Variant Detail

Summary

• QTL variant: Eae41^C57BL/10SnSg
• Name: experimental allergic encephalomyelitis susceptibility 41; C57BL/10SnSg
• MGI ID: MGI:3530273
• Synonyms: Eae41^{B10.RIII-H2/SgKljLund>}
• QTL: Eae41 Location: Chr16:40399134-78015472 bp Genetic Position: Chr16, Syntenic

Variant origin

• Strain of Specimen: B10.RIII-H2^r/SgKljLund

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers EAE susceptibility in male animals compared to RIIIS/J. (J:96204)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Notes

Homozygosity for B10.RIII-derived alleles confer EAE susceptibility at this locus.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96204

Linkage analysis was performed on 402 animals from a B10.RIII-H2^r/SgKljLund x RIIIS/J)F1 x B10.RIII-H2^r/SgKljLund backcross to identify QTLs associated with experimental autoimmune encephalomyelitis (EAE) traits. Parental strain B10.RIII-H2^r/SgKljLund is susceptible to developing EAE upon immunization with myelin basic protein (MBP) 89-101 peptide whereas parental strain RIIIS/J is resistant. 150 microsatellite markers were used for the genome scan.

A locus on mouse Chromosome 16 overlapping with previously identified QTL Eae11 showed linkage to time of disease onset in male animals. This locus is flanked by D16Mit64 (20 cM) and D16Mit50 (47.6 cM) with a peak at D16Mit84. Homozygosity for B10.RIII-H2^r/SgKljLund-derived alleles confer EAE susceptibility at this locus.

6.30.2015 Curators Note: Because Eae11 was originally mapped in J:53191 in 1999 using (SJL/J x B10.S/DvTe)F2 mice, which differ from the cross used here, we consider the current study a separate mapping experiment and have named this QTL Eae41.

References

• Original: J:96204 Karlsson J, et al., Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. J Immunol. 2003 Jan 15;170(2):1019-26
• All: 1 reference(s)