Gjc1^tm1Weil
Targeted Allele Detail

Summary

• Symbol: Gjc1^tm1Weil
• Name: gap junction protein, gamma 1; targeted mutation 1, Reto Weiler
• MGI ID: MGI:3530292
• Synonyms: Cx45flox
• Gene: Gjc1 Location: Chr11:102690405-102710526 bp, - strand Genetic Position: Chr11, 66.48 cM
• Alliance: Gjc1^tm1Weil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95984
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 remained flanked by loxP sites following FLP mediated excision of a neo from intron 2. An EGFP was left in intron 3. (J:95984)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gjc1 Mutation: 33 strains or lines available

References

• Original: J:95984 Maxeiner S, et al., Deletion of connexin45 in mouse retinal neurons disrupts the rod/cone signaling pathway between AII amacrine and ON cone bipolar cells and leads to impaired visual transmission. J Neurosci. 2005 Jan 19;25(3):566-76
• All: 22 reference(s)