Dap3^{Gt(OST147863)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Dap3^{Gt(OST147863)Lex}
• Name: death associated protein 3; gene trap OST147863, Lexicon Genetics
• MGI ID: MGI:3530362
• Synonyms: dap3^-, Dap3^{Gt(neo)450Lex}
• Gene: Dap3 Location: Chr3:88828110-88858488 bp, - strand Genetic Position: Chr3, 39.01 cM, cytoband F2
• Alliance: Dap3^{Gt(OST147863)Lex} page

Mutation origin

• Mutant Cell Line: OST147863
• Germline Transmission: Earliest citation of germline transmission: J:129756
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector containing a beta-geo cassette inserted into intron 1 of the gene. Gene inactivation was confirmed by no detection of the protein product in western blots of E9.5 embryos. (J:129756)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST147863	CG547297 ; (MGI Seq Detail)	3' RACE	Chr3:88837847-88850136 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  24 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dap3 Mutation: 35 strains or lines available

References

• Original: J:129756 Kim HR, et al., Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis. FASEB J. 2007 Jan;21(1):188-96
• All: 2 reference(s)