Frat2^tm2Brn
Targeted Allele Detail

Summary

• Symbol: Frat2^tm2Brn
• Name: frequently rearranged in advanced T cell lymphomas 2; targeted mutation 2, Anton Berns
• MGI ID: MGI:3530463
• Gene: Frat2 Location: Chr19:41834411-41836571 bp, - strand Genetic Position: Chr19, 35.33 cM
• Alliance: Frat2^tm2Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96034
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 635-bp of the coding sequence was replaced with a cassette containing a lacZ reporter gene and puromycin selection gene. (J:96034)

Disease models

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Frat2 Mutation: 11 strains or lines available

Notes

To generate Frat1/Frat2 double mutant mice, Frat1^tm1Brnheterozygous ES cells were targeted with the Frat2 knockout construct.

References

• Original: J:96034 van Amerongen R, et al., Frat is dispensable for canonical Wnt signaling in mammals. Genes Dev. 2005 Feb 15;19(4):425-30
• All: 1 reference(s)