Kdr^tm1.1Msh
Targeted Allele Detail

Summary

• Symbol: Kdr^tm1.1Msh
• Name: kinase insert domain protein receptor; targeted mutation 1.1, Masabumi Shibuya
• MGI ID: MGI:3530468
• Synonyms: Flk-1^1173F
• Gene: Kdr Location: Chr5:76093487-76139118 bp, - strand Genetic Position: Chr5, 40.23 cM
• Alliance: Kdr^tm1.1Msh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96124
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting vector was designed to introduce substitution Y1173F (TAT to TTC) into exon 27. Crossing with mice expressing cre in the germ line deleted a floxed neo from intron 26. Expression levels at E8.5-E9.5 were normal as shown by RT-PCR. (J:96124)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kdr Mutation: 74 strains or lines available

References

• Original: J:96124 Sakurai Y, et al., Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1076-81
• All: 1 reference(s)