Rtn4r^tm1Matl
Targeted Allele Detail

Summary

• Symbol: Rtn4r^tm1Matl
• Name: reticulon 4 receptor; targeted mutation 1, Marc Tessier-Lavigne
• MGI ID: MGI:3530480
• Synonyms: NgR^-, NgR1^-, Ngr1^taulacZ
• Gene: Rtn4r Location: Chr16:17945506-17970272 bp, + strand Genetic Position: Chr16, 11.23 cM, cytoband B1
• Alliance: Rtn4r^tm1Matl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96121
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-TAU-LacZ and a floxed neo replaced most of the coding sequence in exon 2 by homologous recombination. Any transcript translated would be only the first 19 amino acids. Northern blot of mutant brain tissues demonstrated the absence of a wild-type transcript and confirmed the creation of a null allele. (J:96121)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rtn4r Mutation: 24 strains or lines available

References

• Original: J:96121 Zheng B, et al., Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1205-10
• All: 15 reference(s)