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Magi1Gt(OST33326)Lex
Gene trapped Allele Detail
Summary
Symbol: Magi1Gt(OST33326)Lex
Name: membrane associated guanylate kinase, WW and PDZ domain containing 1; gene trap OST33326, Lexicon Genetics
MGI ID: MGI:3530498
Synonyms: Magi1Gt(Betageo)475Lex
Gene: Magi1  Location: Chr6:93652436-94260898 bp, - strand  Genetic Position: Chr6, 42.7 cM, cytoband D3
Alliance: Magi1Gt(OST33326)Lex page
Mutation
origin
Mutant Cell Line:  OST33326
Germline Transmission:  Earliest citation of germline transmission: J:278456
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector
 
Mutation detailsA gene trap vecotr inserted into the first and second exon of the gene resulting in splicing out most of the first intron and inserting a STOP codon at the end of the first exon, and eliminates the full length transcript. Lack of protein expression was confrimed by immunoblot analysis on tissue lysates obtained from mutant and control mice. (J:278456)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Magi1 Mutation:  175 strains or lines available
References
Original:  J:278456 Abe JI, et al., MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis. JCI Insight. 2019 Apr 4;4(7)
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory