Cacna1g^tm1.1Stl
Targeted Allele Detail

Summary

• Symbol: Cacna1g^tm1.1Stl
• Name: calcium channel, voltage-dependent, T type, alpha 1G subunit; targeted mutation 1.1, Susumu Tonegawa
• MGI ID: MGI:3530501
• Synonyms: alpha1G KO
• Gene: Cacna1g Location: Chr11:94299217-94365024 bp, - strand Genetic Position: Chr11, 58.9 cM
• Alliance: Cacna1g^tm1.1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96099
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cacna1g^tm1Stl mice were crossed with mice expressing cre in the germ line and produced this allele in which exons 9-12 were removed. In situ hybridization of mutant brains confirmed the complete loss of transcript. (J:96099)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1g Mutation: 104 strains or lines available

References

• Original: J:96099 Anderson MP, et al., Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1743-8
• All: 5 reference(s)