Fancd2^{Gt(OST57859)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Fancd2^{Gt(OST57859)Lex}
• Name: Fanconi anemia, complementation group D2; gene trap OST57859, Lexicon Genetics
• MGI ID: MGI:3530554
• Synonyms: Fancd2^-, Fancd2^{Gt(IRESBetageo)479Lex}
• Gene: Fancd2 Location: Chr6:113508643-113573978 bp, + strand Genetic Position: Chr6, 52.78 cM, cytoband E3
• Alliance: Fancd2^{Gt(OST57859)Lex} page

Mutation origin

• Mutant Cell Line: OST57859
• Germline Transmission: Earliest citation of germline transmission: J:146616
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• The gene trap inserted between exon 1 and 2. (J:94338, J:168056)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST57859	CG507746 ; (MGI Seq Detail)	3' RACE	Chr6:113512724-113514010 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  24 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	72 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fancd2 Mutation: 82 strains or lines available

References

• Original: J:146616 Kim JM, et al., Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell. 2009 Feb;16(2):314-20
• All: 14 reference(s)