Tg(Ckm-Mkl1)1Eno
Transgene Detail

Summary

• Symbol: Tg(Ckm-Mkl1)1Eno
• Name: transgene insertion 1, Eric N Olson
• MGI ID: MGI:3530559
• Synonyms: MCK-dnMRTF-A
• Transgene: Tg(Ckm-Mkl1)1Eno Location: unknown
• Alliance: Tg(Ckm-Mkl1)1Eno page

Muscle fiber fibrosis in Tg(Ckm-Mkl1)1Eno/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-Mkl1)1Eno expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mrtfa (MGI:2384495)

• Mutation details: This transgene contains the muscle creatine kinase promoter and cDNA encoding the N-terminal 712 amino acids of Mkl1, without the transcription activation domain. Two lines were generated that had the same overall phenotype with varying severity. Line 1 had approximately 4-fold higher expression and a more severe phenotype compared to line 2. This is a representaive record for both lines. (J:96122)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:96122 Li S, et al., Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1082-7
• All: 1 reference(s)