Nod2^tm1Mka
Targeted Allele Detail

Summary

• Symbol: Nod2^tm1Mka
• Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Michael Karin
• MGI ID: MGI:3530578
• Synonyms: Nod2²⁹³⁹, Nod2^mt
• Gene: Nod2 Location: Chr8:89373943-89415102 bp, + strand Genetic Position: Chr8, 43.51 cM, cytoband C3
• Alliance: Nod2^tm1Mka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96128
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A cytosine was inserted at 2939 in exon 11 of the ORF, resulting in a frame-shift leading to a premature stop codon and a truncated protein. The targeting vector contained a neo downstream of the inserted cytosine. RT-PCR and Western blot confirmed successful recombination. (J:96128)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nod2 Mutation: 63 strains or lines available

References

• Original: J:96128 Maeda S, et al., Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science. 2005 Feb 4;307(5710):734-8
• All: 3 reference(s)