Sertad2^{Gt(OST98734)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Sertad2^{Gt(OST98734)Lex}
• Name: SERTA domain containing 2; gene trap OST98734, Lexicon Genetics
• MGI ID: MGI:3530582
• Synonyms: Sertad2^{Gt(neo)490Lex}, TRIP-Br2 KO
• Gene: Sertad2 Location: Chr11:20493253-20603021 bp, + strand Genetic Position: Chr11, 13.03 cM, cytoband A3.2
• Alliance: Sertad2^{Gt(OST98734)Lex} page

Mutation origin

• Mutant Cell Line: OST98734
• Germline Transmission: Earliest citation of germline transmission: J:196054
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted upstream of exon 3. Western blot analysis confirmed the absence of protein expression in epididymal fat tissue of mice fed a high fat diet. (J:196054)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST98734	CG524570 ; (MGI Seq Detail)	3' RACE	Chr11:20597806-20598312 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  83 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Sertad2^Gt(OST98734)Lex/Sertad2^Gt(OST98734)Lex	B6.129S5-Sertad2^Gt(OST98734)Lex
hm2	Sertad2^Gt(OST98734)Lex/Sertad2^Gt(OST98734)Lex	involves: 129S5/SvEvBrd
ht3	Sertad2^Gt(OST98734)Lex/Sertad2^+	B6.129S5-Sertad2^Gt(OST98734)Lex

Phenotypes:

Affected Systems	hm1	hm2	ht3
show or hide all annotated terms
adipose tissue	√
decreased subcutaneous adipose tissue amount	√
decreased brown adipose tissue mass	√
increased brown fat cell number	√
decreased brown fat cell size	√
decreased white fat cell size	√
decreased epididymal fat pad weight	√
decreased percent body fat/body weight	√
cellular		√
decreased fibroblast proliferation		√
growth/size/body	√	√
increased lean body mass	√
decreased body weight	√	√
decreased susceptibility to diet-induced obesity	√	√
hematopoietic system	√
abnormal macrophage physiology	√
homeostasis/metabolism	√	√	√
decreased susceptibility to diet-induced obesity	√	√
increased core body temperature	√
increased oxygen consumption	√
abnormal glucose homeostasis	√
decreased circulating glucose level	√
improved glucose tolerance	√
increased insulin sensitivity	√
abnormal hormone level	√
abnormal circulating hormone level	√
decreased circulating insulin level	√
decreased circulating leptin level	√		√
increased adiponectin level	√
abnormal lipid homeostasis	√
decreased circulating cholesterol level	√		√
decreased liver triglyceride level	√
enhanced lipolysis	√
immune system	√
abnormal macrophage physiology	√
integument	√
decreased subcutaneous adipose tissue amount	√
liver/biliary system	√
decreased liver triglyceride level	√
decreased liver weight	√
decreased susceptibility to diet-induced hepatic steatosis	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sertad2 Mutation: 81 strains or lines available

References

• Original: J:196054 Sim KG, et al., The TRIP-Br family of transcriptional regulators is essential for the execution of cyclin E-mediated cell cycle progression. Cell Cycle. 2006 May;5(10):1111-5
• All: 5 reference(s)