Slc9c1^tm1Gar
Targeted Allele Detail

Summary

• Symbol: Slc9c1^tm1Gar
• Name: solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1; targeted mutation 1, David L Garbers
• MGI ID: MGI:3530647
• Synonyms: NHE^-
• Gene: Slc9c1 Location: Chr16:45355672-45427364 bp, + strand Genetic Position: Chr16, 29.53 cM
• Alliance: Slc9c1^tm1Gar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87248
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 4 and exons 5-11 were replaced with a neo cassette. Northern blot confirmed the presence of a truncated transcript in mutant mice. Neither immunohistochemistry nor Western blot analysis showed the presence of a protein product of this allele. (J:87248)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc9c1 Mutation: 67 strains or lines available

References

• Original: J:87248 Wang D, et al., A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. Nat Cell Biol. 2003 Dec;5(12):1117-22
• All: 5 reference(s)