Chd8^tm1Kei
Targeted Allele Detail

Summary

• Symbol: Chd8^tm1Kei
• Name: chromodomain helicase DNA binding protein 8; targeted mutation 1, Keiichi I Nakayama
• MGI ID: MGI:3530648
• Synonyms: Chd8^deltaSL
• Gene: Chd8 Location: Chr14:52435608-52495237 bp, - strand Genetic Position: Chr14, 26.84 cM
• Alliance: Chd8^tm1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92968
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A PGK-lox-neo-polyA cassette replaced all of the exons in the locus. (J:92968)

Disease models

Expression

In Mice Carrying this Mutation:	60 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chd8 Mutation: 107 strains or lines available

References

• Original: J:92968 Nishiyama M, et al., Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol Cell Biol. 2004 Oct;24(19):8386-94
• All: 6 reference(s)