Def6^{Gt(OST307148)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Def6^{Gt(OST307148)Lex}
• Name: differentially expressed in FDCP 6; gene trap OST307148, Lexicon Genetics
• MGI ID: MGI:3530790
• Synonyms: Def6^{Gt(neo)551Lex}, Def6^trap, IBP^trap
• Gene: Def6 Location: Chr17:28426752-28447582 bp, + strand Genetic Position: Chr17, 14.64 cM
• Alliance: Def6^{Gt(OST307148)Lex} page

Mutation origin

• Mutant Cell Line: OST307148
• Germline Transmission: Earliest citation of germline transmission: J:106469
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector integrated into the first intron of the locus, downstream of the exon containing the ATG. Western blot failed to detect protein in mutants. (J:106469)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST307148	CG615826 ; (MGI Seq Detail)	3' RACE	Chr17:28435946-28436683 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  11 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Def6 Mutation: 43 strains or lines available

References

• Original: J:106469 Fanzo JC, et al., Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity. J Clin Invest. 2006 Mar;116(3):703-14
• All: 21 reference(s)