S100a1^{Gt(OST28275)Lex}
Gene trapped Allele Detail

Summary

• Symbol: S100a1^{Gt(OST28275)Lex}
• Name: S100 calcium binding protein A1; gene trap OST28275, Lexicon Genetics
• MGI ID: MGI:3530818
• Synonyms: S100a1^{Gt(IRESBetageo)567Lex}
• Gene: S100a1 Location: Chr3:90418341-90421637 bp, - strand Genetic Position: Chr3, 39.24 cM, cytoband F1-F2
• Alliance: S100a1^{Gt(OST28275)Lex} page

Mutation origin

• Mutant Cell Line: OST28275
• Germline Transmission: Earliest citation of germline transmission: J:117944
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A retroviral gene trap was located in the second intron of the locus, disrupting the coding region midway. The vector contained a splice acceptor, IRES-betageo, polyA, PGK-puro, and splice donor. (J:117944)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST28275	CG490964 ; (MGI Seq Detail)	3' RACE	Chr3:90418341-90418670 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  15 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S100a1 Mutation: 12 strains or lines available

References

• Original: J:117944 Ackermann GE, et al., S100A1-deficient male mice exhibit increased exploratory activity and reduced anxiety-related responses. Biochim Biophys Acta. 2006 Nov;1763(11):1307-19
• All: 3 reference(s)