Slc7a7^{Gt(OST41878)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Slc7a7^{Gt(OST41878)Lex}
• Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 7; gene trap OST41878, Lexicon Genetics
• MGI ID: MGI:3530880
• Synonyms: Slc7a7^-, Slc7a7^{Gt(IRESBetageo)613Lex}
• Gene: Slc7a7 Location: Chr14:54606899-54655237 bp, - strand Genetic Position: Chr14, 27.76 cM, cytoband C1
• Alliance: Slc7a7^{Gt(OST41878)Lex} page

Mutation origin

• Mutant Cell Line: OST41878
• Germline Transmission: Earliest citation of germline transmission: J:125847
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector containing a splice acceptor, beta-geo cassette and a pA was inserted into the second intron. The alteration of a transcript was confirmed by northern blot analysis on RNA extracted from kidney with probe for the two exons flanking the insertion. (J:125847)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST41878	CG499625 ; (MGI Seq Detail)	3' RACE	Chr14:54612016-54612078 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  111 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc7a7 Mutation: 78 strains or lines available

References

• Original: J:125847 Sperandeo MP, et al., Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance. Am J Physiol Cell Physiol. 2007 Jul;293(1):C191-8
• All: 2 reference(s)