Hmgb1^tm1Meb
Targeted Allele Detail

Summary

• Symbol: Hmgb1^tm1Meb
• Name: high mobility group box 1; targeted mutation 1, Marco E Bianchi
• MGI ID: MGI:3530901
• Synonyms: Hmg1^-
• Gene: Hmgb1 Location: Chr5:148983512-148989867 bp, - strand Genetic Position: Chr5, 89.18 cM
• Alliance: Hmgb1^tm1Meb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55880
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 2, 3, 4, and 5 of the gene was replaced by the insertion of a neo cassette. (J:55880)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgb1 Mutation: 17 strains or lines available

References

• Original: J:55880 Calogero S, et al., The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice [see comments]. Nat Genet. 1999 Jul;22(3):276-80
• All: 15 reference(s)